Marzyeh Amini is a scientific researcher with a background in epidemiology and clinical research. With a master’s degree in biomedical science from the Tehran University of Medical Science and extensive epidemiological methodological training from Erasmus University Medical Centre and University Medical Centre of Groningen, she has developed her skills in data analysis, designing and executing of (non)interventional studies, real-world evidence (RWE) generation, and project management. The focus of her PhD at Erasmus University was on the methodological challenges of measuring quality of care indicators and their implementation on clinical practice and how to overcome challenges such as missing data and database heterogeneity for benchmarking of hospitals performance.

In her current role as an epidemiologist at DARWIN EU® initiative, she is generating RWE in request by EMA by doing feasibility assessment, developing protocols and reports, and data results visualization through effective collaboration with internal and external stakeholders.

Publications

López-Lacort M, Amini M, Emborg HD, Nielsen J, McDonald SA, Valentiner-Branth P, Díez-Domingo J, Orrico-Sánchez A. Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain. J Infect Dis. 2024. doi: 10.1093/infdis/jiae088

van Linschoten RCA, Amini M, van Leeuwen N, Eijkenaar F, den Hartog SJ, Nederkoorn PJ, Hofmeijer J, Emmer BJ, Postma AA, van Zwam W, et al. Handling missing values in the analysis of between-hospital differences in ordinal and dichotomous outcomes: a simulation study. BMJ Qual Saf. 2023;32:742-749. doi: 10.1136/bmjqs-2023-016387

Amini M, Eijkenaar F, Lingsma HF, den Hartog SJ, Olthuis SGH, Martens J, van der Worp B, van Zwam W, van der Hoorn A, Roosendaal SD, et al. Validity of Early Outcomes as Indicators for Comparing Hospitals on Quality of Stroke Care. Journal of the American Heart Association. 2023;12:e027647. doi: 10.1161/JAHA.122.027647

Olthuis SGH, Hinsenveld WH, Pinckaers FME, Amini M, Lingsma HF, Staals J, Hcml Schreuder T, Schonewille WJ, Yo LSF, Bwem Roos Y, et al. Association between type of intervention center and outcomes after endovascular treatment for acute ischemic stroke: Results from the MR CLEAN Registry. European Stroke Journal. 2022;8:224-230. doi: 10.1177/23969873221145771

Amini M, van Leeuwen N, Eijkenaar F, van de Graaf R, Samuels N, van Oostenbrugge R, van den Wijngaard IR, van Doormaal PJ, Roos YBWEM, Majoie C, et al. Estimation of treatment effects in observational stroke care data: comparison of statistical approaches. BMC Medical Research Methodology. 2022;22:103. doi: 10.1186/s12874-022-01590-0

Amini M, den Hartog SJ, van Leeuwen N, Eijkenaar F, Kuhrij LS, Stolze LJ, Nederkoorn PJ, Lingsma HF, van Es ACGM, van den Wijngaard IR, et al. Performance feedback on the quality of care in hospitals performing thrombectomy for ischemic stroke (PERFEQTOS): protocol of a stepped wedge cluster randomized trial. Trials. 2021;22:870. doi: 10.1186/s13063-021-05819-z

Amini M, van Leeuwen N, Eijkenaar F, Mulder MJHL, Schonewille W, Lycklama à Nijeholt G, Hinsenveld WH, Goldhoorn R-JB, van Doormaal PJ, Jenniskens S, et al. Improving quality of stroke care through benchmarking center performance: why focusing on outcomes is not enough. BMC Health Services Research. 2020;20:998. doi: 10.1186/s12913-020-05841-y

Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupović H, Chasman DI, Manning A, Ntalla I, et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications. 2019;10:376. doi: 10.1038/s41467-018-08008-w

Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018;102:375-400. doi: 10.1016/j.ajhg.2018.01.015

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng CY, Sim X, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One. 2018;13:e0198166. doi: 10.1371/journal.pone.0198166

Amini M, Vonk JM, Abbasi A, Prins BP, Bruinenberg M, Franke L, van der Harst P, Navis G, Koppelman GH, Wolffenbuttel BHR, et al. Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes: A Mendelian Randomization Study. Twin Res Hum Genet. 2018;21:89-100. doi: 10.1017/thg.2018.6

van den Berg EH, van Tienhoven-Wind LJN, Amini M, Schreuder TCMA, Faber KN, Blokzijl H, Dullaart RPF. Higher free triiodothyronine is associated with non-alcoholic fatty liver disease in euthyroid subjects: the Lifelines Cohort Study. Metabolism. 2017;67:62-71. doi: https://doi.org/10.1016/j.metabol.2016.11.002

van den Berg EH, Amini M, Schreuder TCMA, Dullaart RPF, Faber KN, Alizadeh BZ, Blokzijl H. Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort. PLOS ONE. 2017;12:e0171502. doi: 10.1371/journal.pone.0171502

Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics. 2017;49:834-841. doi: 10.1038/ng.3841

Amini M, Bashirova D, Prins BP, Corpeleijn E, LifeLines Cohort S, Bruinenberg M, Franke L, Harst Pvd, Navis G, Wolffenbuttel BHR, et al. Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study. PLOS ONE. 2016;11:e0168480. doi: 10.1371/journal.pone.0168480

Rahimi M, Vinciguerra M, Daghighi M, Özcan B, Akbarkhanzadeh V, Sheedfar F, Amini M, Mazza T, Pazienza V, Motazacker MM, et al. Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. Oncotarget. 2015;6:29818-29832. doi: 10.18632/oncotarget.4904

Malekzadeh MM, Radmard AR, Nouroozi A, Akbari MR, Amini M, Navabakhsh B, Caleffi A, Pietrangelo A, Malekzadeh R. Juvenile Hemochromatosis, Genetic Study and Long-term Follow up after Therapy. Middle East J Dig Dis. 2014;6:87-92.

Nahrevanian H, Esmaeili B, Kazemi M, Nazem H, Amini M. In Vivo Antimalarial Effects of Iranian Flora Artemisia khorassanica against Plasmodium berghei and Pharmacochemistry of its Natural Components. Iran J Parasitol. 2010;5:6-19.

Amini M, Nahrevanian H, Khatami S, Farahmand M, Mirkhani F, Javadian S. Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice. Braz J Infect Dis. 2009;13:83-85. doi: 10.1590/s1413-86702009000200002