Maria de Ridder, PhD


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Maria de Ridder is statistician working in the Department of Medical Informatics of the Erasmus MC, the Netherlands. She obtained the diploma Statistician of  the Dutch Society of Statistics and Operations Research and an MSc in Clinical Epidemiology. The topic of her PhD thesis was prediction models for growth studies. From her job, first at the Department of Biostatistics, she has a wide experience of analysing clinical and epidemiological studies, as well as advising in design and assimilating results. She collaborated in several multi-database studies in which she was involved in several aspects: design, planning of statistical analyses, converting input data to analysis data, writing analysis code to be run at different sites, conduct analyses, combining analysis results with meta-analysis, reporting of results and conclusions. She is also one of the methodologists in the Medical research Ethics Committees United.

Recent publications

  • Gritter M, Wouda RD, Yeung SMH, Wieërs MLA, Geurts F, de Ridder MAJ, Ramakers CRB, Vogt L, de Borst MH, Rotmans JI, Hoorn EJ. Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD. J Am Soc Nephrol. 2022 September, 33 (9): 1779-1789


    Arinze JT, Hofman A, de Roos EW, de Ridder MAJ, Verhamme KMC, Stricker B, Brusselle GG, Luik AI. The interrelationship of chronic cough and depression: a prospective population-based study. ERJ Open Res. 2022 Apr 4;8(2):00069-2022.


    Baan EJ, de Roos EW, Engelkes M, de Ridder M, Pedersen L, Berencsi K, Prieto-Alhambra D, Lapi F, Van Dyke MK, Rijnbeek P, Brusselle GG, Verhamme KMC. Characterization of Asthma by Age of Onset: A Multi-Database Cohort Study J Allergy Clin Immunol Pract. 2022 Jul;10(7):1825-1834.

  • de Ridder MAJ, de Wilde M, de Ben C, Leyba AR, Mosseveld BMT, Verhamme KMC, van der Lei J, Rijnbeek PR. Data Resource Profile: The Integrated Primary Care Information (IPCI) database, The Netherlands. Int J Epidemiol. 2022 Feb 19:dyac026. doi: 10.1093/ije/dyac026. Epub ahead of print. PMID: 35182144.

  • Yang C, Kors JA, Ioannou S, John LH, Markus AF, Rekkas A, de Ridder MAJ, Seinen TM, Williams RD, Rijnbeek PR. Trends in the conduct and reporting of
    clinical prediction model development and validation: a systematic review. J Am Med Inform Assoc. 2022 Jan 19:ocac002. doi: 10.1093/jamia/ocac002. Epub ahead of print. PMID: 35045179.

  • Benz E, Wijnant SRA, Trajanoska K, Arinze JT, de Roos EW, de Ridder M, Williams R, van Rooij F, Verhamme KMC, Ikram MA, Stricker BH, Rivadeneira F,
    Lahousse L, Brusselle GG. Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma: a population-based study. ERJ Open Res. 2022 Jan 10;8(1):00628-2021. 

  • Baan EJ, Hoeve CE, De Ridder M, Demoen L, Lahousse L, Brusselle GG, Verhamme KMC. The ALPACA study: (In)Appropriate LAMA prescribing in asthma: A cohort analysis. Pulm Pharmacol Ther. 2021 Dec;71:102074. 

  • Aaboubout Y, van der Toom QM, de Ridder MAJ, De Herdt MJ, van der Steen B, van Lanschot CGF, Barroso EM, Nunes Soares MR, Ten Hove I, Mast H, Smits RWH, Sewnaik A, Monserez DA, Keereweer S, Caspers PJ, Baatenburg de Jong RJ, Bakker Schut TC, Puppels GJ, Hardillo JA, Koljenović S. Is the Depth of Invasion a Marker for Elective Neck Dissection in Early Oral Squamous Cell Carcinoma? Front Oncol. 2021 Mar 12;11:628320. 

  • Smits RWH, van Lanschot CGF, Aaboubout Y, de Ridder M, Hegt VN, Barroso EM, Meeuwis CA, Sewnaik A, Hardillo JA, Monserez D, Keereweer S, Mast H, Hove IT, Bakker Schut TC, Baatenburg de Jong RJ, Puppels GJ, Koljenović S. Intraoperative Assessment of the Resection Specimen Facilitates Achievement of Adequate Margins in Oral Carcinoma. Front Oncol. 2020 Dec 23;10:614593..

  • Heikema AP, Horst-Kreft D, Boers SA, Jansen R, Hiltemann SD, de Koning W, Kraaij R, de Ridder MAJ, van Houten CB, Bont LJ, Stubbs AP, Hays JP. Comparison of Illumina versus Nanopore 16S rRNA Gene Sequencing of the Human Nasal Microbiota. Genes (Basel). 2020 Sep 21;11(9):E1105
  • van Lanschot CGF, Klazen YP, de Ridder MAJ, Mast H, Ten Hove I, Hardillo JA, Monserez DA, Sewnaik A, Meeuwis CA, Keereweer S, Aaboubout Y, Barroso EM, van der Toom QM, Bakker Schut TC, Wolvius EB, Baatenburg de Jong RJ, Puppels GJ, Koljenovic S. Depth of invasion in early stage oral cavity squamous cell carcinoma: The optimal cut-off value for elective neck dissection. Oral Oncol. 2020 Aug 5; 111:104940.
  • Dodd C, de Ridder M, Weibel D, Mahaux O, Haguinet F, de Smedt T, de Lusignan S, McGee C, Duarte-Salles T, Emborg HD, Huerta C, Martín-Merino E, Picelli G, Berencsi K, Danieli G, Sturkenboom M. ADVANCE system testing: Estimating the incidence of adverse events following pertussis vaccination in healthcare databases with incomplete exposure data. Vaccine. 2020 Apr 9:S0264-410X(20)30439-4. 
  • Engelkes M, de Ridder MA, Svensson E, Berencsi K, Prieto-Alhambra D, Lapi F, Giaquinto C, Picelli G, Boudiaf N, Albers FC, Cockle SM, Bradford ES, Suruki RY, Brusselle GG, Rijnbeek PR, Sturkenboom MC, Verhamme KM. Multinational cohort study of mortality in patients with asthma and severe asthma. Respir Med. 2020 Apr-May;165:105919. 
  • Engelkes M, Baan EJ, de Ridder MAJ, Svensson E, Prieto-Alhambra D, Lapi F, Giaquinto C, Picelli G, Boudiaf N, Albers F, Evitt LA, Cockle S, Bradford E, Van Dyke MK, Suruki R, Rijnbeek P, Sturkenboom MCJM, Janssens HM, Verhamme KMC. Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study. Pediatr Allergy Immunol. 2020 Mar 1.
  • Tin Tin Htar M, de Ridder M, Braeye T, Correa A, McGee C, de Lusignan S, Duarte-Salles T, Huerta C, Martín-Merino E, Tramontan L, Danieli G, Picelli G, van der Maas N, Berencsi K, Arnheim-Dahlström L, Heininger U, Emborg HD, Weibel D, Bollaerts K, Sturkenboom M. Advance system testing: Vaccine benefit studies using multi-country electronic health data - The example of pertussis vaccination. Vaccine. 2019 Oct 31:S0264-410X(19)31167-3. 
  • Sultana J, Leal I, de Wilde M, de Ridder M, van der Lei J, Sturkenboom M, Trifiro' G. Identifying Data Elements to Measure Frailty in a Dutch Nationwide Electronic Medical Record Database for Use in Postmarketing Safety Evaluation: An Exploratory Study. Drug Saf. 2019 Jun;42(6):713-719. 
  • Gadroen K, Dodd CN, Masclee GMC, de Ridder MAJ, Weibel D, Mina MJ, Grenfell BT, Sturkenboom MCJM, van de Vijver DAMC, de Swart RL. Impact and longevity of measles-associated immune suppression: a matched cohort study using data from the THIN general practice database in the UK. BMJ Open. 2018 Nov 8;8(11):e021465. 
  • Dodd CN, de Ridder M, Huang WT, Weibel D, Giner-Soriano M, Perez-Vilar S, Diez-Domingo J, Svenson LW, Mahmud SM, Carleton B, Naus M, Kwong JC, Murray BJ, Arnheim-Dahlstrom L, Pedersen L, Morros R, Puertas FJ, Black S, Sturkenboom M. Incidence rates of narcolepsy diagnoses in Taiwan, Canada, and Europe: The use of statistical simulation to evaluate methods for the rapid assessment of potential safety issues on a population level in the SOMNIA study. PLoS One.2018 Oct 17;13(10):e0204799. 
  • Weibel D, Sturkenboom M, Black S, de Ridder M, Dodd C, Bonhoeffer J, Vanrolleghem A, van der Maas N, Lammers GJ, Overeem S, Gentile A, Giglio N, Castellano V, Kwong JC, Murray BJ, Cauch-Dudek K, Juhasz D, Campitelli M, Datta AN, Kallweit U, Huang WT, Huang YS, Hsu CY, Chen HC, Giner-Soriano M, Morros R, Gaig C, Tió E, Perez-Vilar S, Diez-Domingo J, Puertas FJ, Svenson LW, Mahmud SM, Carleton B, Naus M, Arnheim-Dahlström L, Pedersen L, DeStefano F, ShimabukuroTT. Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines - Multi-country assessment. Vaccine. 2018 Oct 1;36(41):6202-6211
  • Osokogu OU, Khan J, Nakato S, Weibel D, de Ridder M, Sturkenboom MCJM, Verhamme K. Choice of time period to identify confounders for propensity score matching, affected the estimate: a retrospective cohort study of drug effectiveness in asthmatic children. J Clin Epidemiol. 2018 Sep;101:107-115.e3.
  • Poluzzi E, Diemberger I, De Ridder M, Koci A, Clo M, Oteri A, Pecchioli S, Bezemer I, Schink T, Pilgaard Ulrichsen S, Boriani G, Sturkenboom MCJ, De Ponti F, Trifirò G. Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project. Eur J Clin Pharmacol. 2017 Nov;73(11):1499-1510. 
  • La Gamba F, Corrao G, Romio S, Sturkenboom M, Trifirò G, Schink T, de Ridder M. Combining evidence from multiple electronic health care databases: performances of one-stage and two-stage meta-analysis in matched case-control studies. Pharmacoepidemiol Drug Saf. 2017 Oct;26(10):1213-1219
  • Perez-Vilar S, Weibel D, Sturkenboom M, Black S, Maure C, Castro JL, Bravo-Alcántara P, Dodd CN, Romio SA, de Ridder M, Nakato S, Molina-León HF, Elango V, Zuber PLF; WHO Global Vaccine Safety-Multi Country Collaboration. Enhancing global vaccine pharmacovigilance: Proof-of-concept study on aseptic meningitis and immune thrombocytopenic purpura following measles-mumps containing vaccination. Vaccine. 2018 Jan 8;36(3):347-354
  • Trifirò G, de Ridder M, Sultana J, Oteri A, Rijnbeek P, Pecchioli S, Mazzaglia G, Bezemer I, Garbe E, Schink T, Poluzzi E, Frøslev T, Molokhia M, Diemberger I, Sturkenboom MCJM. Use of azithromycin and risk of ventricular arrhythmia. CMAJ. 2017 Apr 18;189(15):E560-E568. 
  • de Bie S, Kaguelidou F, Verhamme KM, De Ridder M, Picelli G, Straus SM, Giaquinto C, Stricker BH, Bielicki J, Sharland M, Sturkenboom MC; ARPEC study. Using Prescription Patterns in Primary Care to Derive New Quality Indicators for Childhood Community Antibiotic Prescribing. Pediatr Infect Dis J. 2016 Dec;35(12):1317-1323. 
  • Joore IK, Twisk DE, Vanrolleghem AM, de Ridder M, Geerlings SE, van Bergen JE, van den Broek IV. The need to scale up HIV indicator condition-guided testing for early case-finding: a case-control study in primary care. BMC Fam Pract. 2016 Nov 17;17(1):161. 
  • Huijgen NA, de Ridder MA, Verhamme KM, Dohle GR, Vanrolleghem AM, Sturkenboom MC, Laven JS, Steegers-Theunissen RP. Are proton-pump inhibitors harmful for the semen quality of men in couples who are planning pregnancy? Fertil Steril. 2016 Dec;106(7):1666-1672.e2. 
  • Engelkes M, Janssens HM, de Ridder MA, Sturkenboom MC, de Jongste JC, Verhamme KM. Real life data on incidence and risk factors of severe asthma exacerbations in children in primary care. Respir Med. 2016 Oct;119:48-54. 
  • Blok CG, de Ridder MA, Verhamme KM, Moorman PW. Hypertension in older patients, a retrospective cohort study. BMC Geriatr. 2016 Jul 19;16:142. 
  • Wijnans L, Dodd C, de Ridder M, Romio S, Weibel D, Overeem S, Lammers GJ, Bonhoeffer J, Black S, Sturkenboom M. Pandemic influenza vaccine & narcolepsy: simulations on the potential impact of bias. Expert Rev Vaccines. 2016 May;15(5):573-84. 
  • Sultana J, Leal I, de Ridder M, Sturkenboom M, Trifiró G. Antipsychotic use in dementia patients in a general practice setting: a Dutch population-based study. Epidemiol Psychiatr Sci. 2016 Aug;25(4):403-6. 
  • de Ridder MA, de Vries T, Arends LR. Getting maximum information out of a continuous outcome: applying linear regression. EuroIntervention. 2015 Oct;11(6):718-22. 
  • Engelkes M, Janssens HM, de Ridder MA, de Jongste JC, Sturkenboom MC, Verhamme KM. Time trends in the incidence, prevalence and age at diagnosis of asthma in children. Pediatr Allergy Immunol. 2015 Jun;26(4):367-74. 
  • Renes JS, Willemsen RH, Mulder JC, Bakker-van Waarde WM, Rotteveel J, Oostdijk W, Houdijk EC, Westerlaken C, Noordam C, Verrijn Stuart AA, Odink RJ, de Ridder MA, Hokken-Koelega AC. New insights into factors influencing adult height in short SGA children: Results of a large multicentre growth hormone trial. Clin Endocrinol (Oxf). 2015 Jun;82(6):854-61. 
  • Schurink-Van't Klooster TM, de Ridder MA, Kemmeren JM, van der Lei J, Dekker F, Sturkenboom M, de Melker HE. Examining a possible association between human papilloma virus (HPV) vaccination and migraine: results of a cohort study in the Netherlands. Eur J Pediatr. 2015 May;174(5):641-9.